IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Space-maker hydrolases and their role in enlargement of bacterial cell wall 
 
Wed, Oct 10, 2018,   12:00 AM to 01:00 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Manjula Reddy
CSIR-Centre for Cellular and Molecular Biology, Hyderabad

Abstract:

Bacteria are a large group of ubiquitous unicellular microorganisms. To protect themselves against both extracellular stress and intracellular osmotic pressure, most bacteria are surrounded by a thick cell wall that consists of a mesh-like exoskeleton called peptidoglycan (PG) sacculus. PG is made up of multiple overlapping glycan strands interlinked by short peptide chains and forms a net-like structure around the bacterial cytoplasmic membrane. Because PG completely encases the cytoplasmic membrane, cleavage of peptide cross-links is a prerequisite to open up the meshes and make space to incorporate nascent glycan strands for its successful enlargement during growth of a cell. Here, the significance of cross-link cleavage during expansion of PG and its regulation will be discussed.

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