IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

WNT/Ã�-Catenin Signaling in Prostate Cancer Progression 
 
Tue, Jan 01, 2019,   11:30 AM to 12:30 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Rachana Patel
The Beatson Institute for Cancer Research, Scotland

Abstract:

Androgen receptor (AR) antagonism is a major strategy to treat advanced prostate cancers. Despite the prevalence of ß-catenin mutations in many cancer types, genomic alterations in ß-catenin are associated with treatment-resistance only in prostate cancer. Here, we have investigated the relevance of ß-catenin activating mutation in prostate cancer progression. We find that ß-catenin activation decreases Pten expression and, independent of the cell-of-origin, ß-catenin activation and Pten haploinsufficiency cooperate to mediate AR-deficient metastatic castration-resistant prostate cancer. ß-catenin mutant prostate tumours rely on WNT5a, a non-canonical WNT ligand for sustained growth. Overall, WNT/ß-catenin and AR signalling are reciprocally inhibited. Therefore, inhibiting WNT/ß-catenin signalling by limiting WNT secretion along with AR inhibition may be useful in treating prostate cancers with ß-catenin mutations.

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