IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Role for intracellular Ca2+ signalling in regulating neuropeptides required for Drosophila development under nutritional stress. 
 
Mon, Feb 18, 2019,   11:00 AM to 12:00 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Megha
Wellcome Trust, DBT-India Alliance Early Career Fellow National Centre for Biological Science (NCBS-TIFR), Bangalore

Abstract:

Post-fertilization, a tightly orchestrated sequence of time-sensitive events leads to the emergence of a fully developed animal. A sufficient supply of nutrients is essential for this process, but a disruption in supply does not necessarily halt development or delay it indefinitely. To investigate the biology underpinning this phenomenon, Drosophila development on a nutrient restricted diet was used as the model system. We find that intracellular Ca2+ signalling in a class of neurons that make neuropeptides is required for successful larval to pupal development on a nutrient restricted diet. We have now identified a restricted set of neurons that make two specific neuropeptides and uncovered how intracellular Ca2+ signalling regulates them, in order to finally
promote development on poor food. Additionally, I will share preliminary studies on adapting Drosophila as a model to study the effects of childhood malnutrition.
 

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