IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Proteome homeostasis: analysis and visualization of protein degradation - from single cells to tissues 
 
Mon, Mar 04, 2019,   11:30 AM to 12:30 PM at Seminar Room 34, 2nd Floor, Main Building

Prof. Dr. rer. nat. Michael Knop
Group Leader in the DKFZ-ZMBH Alliance ZMBH, Im Neuenheimer Feld 282 69120 Heidelberg, Germany

Abstract:

The ability of cells and tissues to degrade proteins in a selective manner is critical for virtually every important cellular function, from cell division to tissues development. Moreover, impaired protein homeostasis is intrinsically linked to many types of diseases. To overcome major obstacles in the functional investigation of protein homeostasis in the living organism we have developed fluorescent timer proteins that enable the direct visualization of protein turnover in vivo, and also permit mapping of cellular protein turnover pathways and determinants based on high throughput approaches. 
In this lecture I will discuss conceptually the use of fluorescent timers and how they can lead to novel insights, for morphogen signaling in embryonic pattering or the mapping of cellular protein quality pathways and protein-turnover determinants. 

 

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