IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Emerging drivers of chromosomal instability and the response to replication stress in triple negative breast cancers. 
 
Mon, Apr 29, 2019,   11:00 AM to 12:30 PM at Seminar Room 34, 2nd Floor, Main Building

Prof. Andrew Tutt
Head of the Division of Breast Cancer Research Director, Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research and Guys\'s Hospital King\'s College, London, UK

Abstract:

 

 

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Breast cancer comprises of a group of diseases many of the most aggressive forms of which are characterised by high levels of chromosome instability that are driven by abnormalities in the DNA damage response. This has opened up the possibility of targeting these abnormalities and exposing tumour specific vulnerabilities. Abnormalities in homologous recombination DNA repair, driven by loss of function of BRCA1 and BRCA2, and the synthetic lethal targeting of these vulnerabilities with PARP inhibitors have been a “poster child” for these approaches.
In my lecture I will address some of the wider analyses of homologous recombination deficiency in breast cancer and some novel drivers of abnormalities in the DNA damage response and maintenance of genome instability in TNBC. I will also discuss a novel mechanism by which HR deficient TNBCs may cope with the replication stress induced by HR deficiency revealed by my laboratory.
 

 

 

 

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