IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Vignettes on protein assembly and design. 
 
Fri, May 10, 2019,   12:00 PM to 01:00 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Shachi Gosavi
NCBS, Bangalore

Abstract:

My group has primarily been working on computational protein folding using molecular dynamics simulations. Specifically, we have been trying to understand how the often conflicting demands of function, folding and stability modulate the energy landscapes of diverse proteins. More recently, we have used computational predictions from our folding simulations to experimentally assemble proteins. We have been able to successfully design 3D-domain-swapped dimers of diverse monomeric proteins. In this talk, I will first talk about both the simulations and the experiments that went into designing these dimers. If time permits, I will also speak about our first attempts at performing experimental consensus protein design.

 

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