IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Fat Secretion from the Liver : New mechanisms, New targets 
 
Wed, Nov 06, 2019,   04:00 PM to 05:30 PM at Seminar Room 34, 2nd Floor, Main Building

Prof. Roop Mallik
Department of Biological Sciences Tata Institute of Fundamental Research (TIFR), Mumbai

Abstract:

Most interestingly, this entire pathway is controlled by insulin, and therefore responds to fed/fasted states of the animal. Insulin signalling activates phospholipase-D to generate phosphatidic acid on LDs, which signals on LDs to recruit kinesin-1 motors, consequently transporting reactive LDs to the smooth-ER inside hepatocytes. Our results provide multiple molecular players for targeted intervention against hyperlipidemia and fatty liver. This possibility is demonstrated using a specific peptide that removes kinesin-1 from LDs and diminishes triglyceride secretion with no apparent effect on cell viability.

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