IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Traffic Control: How cells calibrate motor activity during cell wall morphogenesis. 
 
Thu, Dec 12, 2019,   11:30 AM to 12:30 PM at Seminar Room no. 34, Second Floor

Dr. Anindya Ganguly
Center for Membrane and Cell Physiology Molecular Physiology and Biological Physics University of Virginia, Charlottesville, VA

Abstract:

Construction of the plant cell wall demands harmonized deposition of cellulose and matrix polysaccharides. Cortical microtubules orient the deposition of cellulose by guiding the trajectory of plasma membrane-embedded cellulose synthase complexes. My research shows that vesicles containing matrix polysaccharides are transported by the FRAGILE FIBER 1 kinesin (FRA1 or kinesin-4a) to facilitate their secretion along the cortical microtubules. The cortical microtubule cytoskeleton thus provides a platform to coordinate the delivery of cellulose and matrix polysaccharides. Moreover, the FRA1 kinesin physically interacts with CELLULOSE SYNTHASE-MICROTUBULE UNCOUPLING proteins (CMU) proteins which regulates the lateral stability of cortical microtubules and are important for the microtubule-dependent guidance of cellulose synthase complexes. Interestingly, the plant cell wall growth is developmentally regulated and so is FRA1 activity. Plants regulate the abundance of FRA1 motors by the proteasome-pathway, so that high FRA1 activity in growing cells ensures high rate of secretion of cell wall materials required for rapid cellular expansion. Altogether, my research shows how a kinesin motor along with an intricate network of its interaction partners delicately controls the magnitude of cargo transport during cell wall expansion.

 

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