IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Engineering new assays to reveal the biological design of chromosome segregation machinery 
 
Tue, Mar 03, 2020,   11:00 AM to 12:00 PM at Seminar Room no. 34, Second Floor

Dr. Ajit Joglekar
Cell & Developmental Biology Adjunct: Biophysics, Biomedical Engineering University of Michigan, USA

Abstract:

I will describe work from my lab that seeks to understand the biological design of two cellular systems: the kinetochore and the mitotic checkpoint. The kinetochore is a complex protein machine that moves chromosomes during cell division, while the mitotic checkpoint uses a kinetochore-based signaling mechanism to delay cell division if one or more kinetochores are not properly attached to the mitotic spindle. Both systems have been studied extensively using the reductionist approach, but this information does not fully reveal the cellular ‘logic’ that dictates specific aspects of their design. I will discuss one study in particular that explains how the mitotic checkpoint maximizes the accuracy of chromosome segregation while also minimizing unnecessary delays in cell division. I will also indicate how this work provides the foundation for our goal of building synthetic chromosome segregation machines.

 

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