IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Cell-death and cell-protection form an intertwined regulatory response in the tissue 
 
Wed, Dec 06, 2017,   02:30 PM to 03:20 PM at Seminar Room 34, 2nd Floor, Main Building

Prof. B. J. Rao
Dept. of Biological Sciences, TIFR (Mini-symposium on Physicochemical phenomena and how they shape biological processes - Talk 1)

Tissue-homeostasis mechanism is central to how cells respond to stress signals. We probed Drosophila Wing-disc system during DNA damage stress and uncovered that initiator caspase Dronc upstream regulates DNA repair via a non-apoptotic function which finally culminates into p53-JNK circuitry that in turn regulates cell death and cell protection responses simultaneously. Resultantly, cell autonomously driven homeostasis leads to tissue-compensation during DNA repair compromised situations with no associated phenotypes. The system therefore provides an elegant intertwining of cell death and cell protection circuitry.

 

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