IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
Links
Seminars and Colloquia

Biology

Tuning of receptor tyrosine kinase activity by phosphoinositides 
 
Fri, Sep 14, 2018,   02:30 PM to 03:30 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Raghu Padinjat
National Centre for Biological Sciences, Bangalore.

Abstract:

Phosphatidylinositol-3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor and is critical for normal growth and metabolism. The lipid kinases and phosphatases regulating PIP3 levels are described but mechanisms that control their activity remains unclear. I will discuss our recent work on the regulation of PIP3 levels during insulin receptor activation by phosphatidylinositol 5 phosphate 4-kinase (PIP4K). Depletion of PIP4K increases PIP3 levels and augments sensitivity to insulin through enhanced Class I phosphoinositide 3-kinase (PI3K) activity. Plasma membrane localized PIP4K was sufficient to control PIP3 levels. Animals lacking PIP4K show enhanced insulin dependent phenotypes in vivo and resistance to the metabolic consequences of a high-sugar diet. Thus, PIP4K is required for normal metabolism and development. These findings define PIP4Ks as regulators of receptor tyrosine kinase signalling with implications for growth factor dependent processes including tumour growth, T-cell activation and metabolism.

homecolloquia_seminars