IISER Pune
INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IISER) PUNE
where tomorrow’s science begins today
An Autonomous Institution, Ministry of Human Resource Development, Govt. of India
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Seminars and Colloquia

Biology

Regulation of mitochondrial size and number under mitochondria stress. 
 
Fri, Sep 28, 2018,   11:00 AM to 12:00 PM at Seminar Room 34, 2nd Floor, Main Building

Dr. Manish Jaiswal
Tata Institute of Fundamental Research, Hyderabad

 Abstract:

A healthy pool of mitochondria is essential for neuronal function and survival. In fact, genes that are implicated in mitochondrial dynamics are often linked to neurodegenerative diseases. We conducted a forward genetic screen to study neuronal maintenance through which we identified a series of mutants with altered size or abundance of mitochondria. We found that these changes are often induced as a compensatory response to defects in mitochondrial physiology. In my talk, I will discuss the regulatory mechanism of mitochondrial fusion protein MARF/Mfn2 in order to regulate the size of mitochondria under physiological stress.

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