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Public Lecture by Prof. Ashok Venkitaraman  Jan 08, 2016

As a part of its 10th-year celebrations, IISER Pune is organizing a public lecture on:


Early intervention in cancer through the tumour suppressive mechanisms that control genome stability
Prof. Ashok Venkitaraman
(Medical Research Council Cancer Unit, University of Cambridge, UK)

Date: January 08, 2016

Time: 04:00 pm

Venue: Sir CV Raman Auditorium, IISER, Pune

Abstract: Transition from the pre-malignant to invasive stages of cancer progression in epithelial tissues is accompanied by the inactivation of tumour suppressive mechanisms that control genome stability. I will discuss insights emerging from our lab’s work concerning the cellular and molecular organization of these tumour suppressive mechanisms (eg., 1-4), and new approaches (eg., 5-7) that offer the potential for early clinical intervention through improvements in risk stratification, diagnosis and therapy.
About the Speaker: Prof Venkitaraman is the Ursula Zoellner Professor of Cancer Research at the University of Cambridge, and the Director of the Medical Research Council (MRC) Cancer Cell Unit at the Hutchison/MRC Research Centre. He is a Collaborative Science Chair at inStem and NCBS, Bangalore, and coordinates the Centre for Chemical Biology and Therapeutics there. He was elected a Fellow of the Academy of Medical Sciences, London, in 2001, and as a member of the EMBO European academy, Heidelberg, in 2004.
Selected references:
1. Venkitaraman, A.R. (2014) Science. 343(6178):1470-5.

2. Wickramasinghe, V., Savill, J., Chavali, S., Jonsdottir, A.B., Rajendra, E., Gruner, T., Laskey, R., Babu, M., & Venkitaraman, A.R. (2013) Molecular Cell 51, 737-50.

3. Jeyasekharan, A.D., Liu, Y., Hattori, H., Pisupati, V., Jonsdottir, A.B., Rajendra, E., Lee, M., Sundaramoorthy, E., Schlachter, S., Kaminski, C., Rosenfeld, Y., Sato, K., Savill, J., Ayoub, N. & Venkitaraman, A.R. (2013). Nature Str Mol Biol. 20, 1191-8.

4. Wickramasinghe V, Gonzàlez-Porta M, Perera D, Bartolozzi AR, Sibley CR, Hallegger M, Ule J, Marioni JC, Venkitaraman AR. (2015). Genome Biol 16(1):201-7.

5. Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ. (2015). Chemistry & Biol. 22(6):689-703.

6. Liang, H., Esposito, A., Collin, P., Surana, U. & Venkitaraman, A.R. (2014) Nature Commun. 5:4048. doi: 10.1038/ncomms5048.
7. Ibbeson BM, Laraia L, Alza E, O' Connor CJ, Tan YS, Davies HM, McKenzie G, Venkitaraman A.R., Spring D.R. (2014). Nature Commun. 5:3155. doi: 10.1038/ncomms4155