Histone H4

Genes for histone H4 are present on three different clusters namely cluster 1, 2 and 4. They are expressed in a cell cycle dependent manner (PMID: 2999768). All histone H4 genes code for the same protein (PMID: 20197778). Loss of both, H4 lysine 16 acetylation and H4 lysine 20 trimethylation is a hallmark of cancer (PMID: 15765097). H4 acetylation profile is reported to be the same across different species (PMID: 17194708). CIA (CCG1-interacting factor A)/ASF1 is a histone chaperone complex specific for H3-H4 dimer (PMID: 17293877).

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Histone H4 infosheet
UniprotKB AccessionP62805
Alternative Name(s)
No. of coding genesHistone H4 is coded by following 14 non-allelic gene/s
Gene namehistone cluster 4, H4histone cluster 2, H4bhistone cluster 1, H4ihistone cluster 1, H4ahistone cluster 1, H4dhistone cluster 1, H4fhistone cluster 1, H4khistone cluster 1, H4jhistone cluster 1, H4chistone cluster 1, H4hhistone cluster 1, H4bhistone cluster 1, H4ehistone cluster 1, H4lhistone cluster 2, H4a
Gene symbolHIST4H4HIST2H4BHIST1H4IHIST1H4AHIST1H4DHIST1H4FHIST1H4KHIST1H4JHIST1H4CHIST1H4HHIST1H4BHIST1H4EHIST1H4LHIST2H4A
Promoter region (-700 TSS +300)Get sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequenceGet sequence
Previous Symbol/sH4FMH4FAH4FBH4FCH4FDH4FEH4FGH4FHH4FIH4FJH4FKH4F2, H4FN, HIST2H4, H4/n
AliasesMGC24116H4/oH4/mH4/bH4/c, H4H4/d, H4F2iii, dJ160A22.1H4/e, H4F2ivH4/g, dJ221C16.1H4/hH4/IH4/jH4.k, H4/k
GeneID121504554313829483598360836183628363836483658366836783688370
Chromosomal location12p12.31q21.26p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.16p22.11q21.2
HGNC2051029607479347814782478347844785478747884789479047914794
UnigeneHs.718935Hs.55468Hs.248172Hs.248178Hs.248179Hs.247816Hs.528055Hs.278483Hs.46423Hs.591790Hs.143080Hs.662174Hs.533295Hs.655235
MIM602833602822602823602824602825602826602827602828602829602830602831142750
RefSeq mRNANM_175054.2NM_001034077.4NM_003495.2NM_003538.3NM_003539.3NM_003540.3NM_003541.2NM_021968.3NM_003542.3NM_003543.3NM_003544.2NM_003545.3NM_003546.2NM_003548.2
RefSeq ProteinNP_778224.1 NP_001029249.1 NP_003486.1NP_003529.1NP_003530.1NP_003531.1NP_003532.1NP_068803.1NP_003533.1NP_003534.1NP_003535.1NP_003536.1NP_003537.1NP_003539.1
Disease associationsNo disease associations known for Histone H4

Histone H4 variants Histone H4