Prof. K N Ganesh



Krishna N Ganesh
Professor and Coordinator, Chemistry
Director, IISER Pune
J C Bose Fellow (DST), NCL Pune

E-mail: director at iiserpune.ac.in
              kn.ganesh at iiserpune.ac.in

Website: http://www.iiserpune.ac.in/~kn.ganesh

 
OFFICE :
              Room 101, First Floor, Central Tower
              Sai Trinity Building, Sutarwadi, Pashan
              Pune 411021, India

K N Ganesh

Education and previous work experience

        1967-1972 B.Sc and M.Sc (Bangalore University)
        1972-1977, Ph.D (Delhi University)
        1977-1980, Ph.D (Cambridge University, UK)
        1981-1987, Scientist, Centre for Cellular and Molecular Biology, Hyderabad 1987-2006, Scientist, National Chemical Laboratory, Pune
        1994-2006, Head, Division of Organic Chemistry (Synthesis), NCL, Pune 
        Since July 2006, Professor and Director, IISER Pune

Award and Honors

1985: Science Academy Medal for Young Scientists, Indian National Science Academy, New Delhi.
1993: Fellow, Indian Academy of Sciences, Bangalore
1998: CSIR Bhatnagar Award in Chemical Sciences
1999: Fellow, Indian National Science Academy, Delhi
2004: Silver Medal, Chemical Research Society of India, Bangalore
2005: TWAS Prize in Chemical Sciences
2005: Elected Secretary, Biomolecular Chemistry Division, Sub Committee, IUPAC
2006: JC Bose Fellowship, Department of Science and Technology, India
2006: Fellow, Academy of Sciences for Developing World (TWAS), Trieste


Research interests
      Biomolecular chemistry of nucleic acids, peptides and lipids; drug development; antisense/antigene technology; DNA diagnostics and nanotechnology; chemistry education

Recent Publications

1. Ferrocene-Linked Thymine/Uracil Conjugtes: Base pairing Directed Self-Assembly and Supramolecular Packing. Patwa, A. N.; Gupta, S.; Gonnade, R. G.; Kumar, V. A.; Bhadbhade, M. M.; Ganesh, K. N., J. Org. Chem. 2008, 73, 1508-1515.

2. PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1. Purbey, P. K.; Singh, S.; Pavan Kumar, P.; Mehta, S.; Ganesh, K. N.; Mitra, D.; Galande, S. Nucleic Acids Res. 2008, 1-16.

3. Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties. Vysabhattar, R.; Ganesh, K. N., Tetrahedron Lett. 2008, 49, 1314-1318.

4. a-Aminoisobutyric acid PNA (aeaib-PNA): Sterically constrained peptide nucleic acids that stabilize PNA:DNA and RNA complexes with preference for DNA binding. Gourishankar, A. and Ganesh, K. N., Chemistry Asian J. 2008

5. V. A. Kumar and K. N. Ganesh Structure-Editing of Nucleic Acids for Selective Targeting of RNA, Curr. Top. Med. Chem, 2007, 7, 715-726.

6. K. N. Ganesh and V. A. Kumar, Conformationally constrained PNA analogs: Structural evolution towards DNA/RNA binding selectivity, Acc. Chem. Res. 2005, 38, 404-412.

7. T. Govindaraju, V. A. Kumar and K. N. Ganesh, (SR/RS)-cyclohexanyl PNAs: Conformationally preorganised PNA analogues with unprecedented preference for duplex formation with RNA, J. Am. Chem. Soc. 2005, 127, 4144-4145.

8. D. H. Dandekar, K. N. Ganesh and D. Mitra, HIV-1 Tat directly binds to NF?B enhancer sequence: Role in viral and cellular gene expression, Nucleic Acids Res. 2004, 32, 1270-1278.

9. Gourishankar, S. Shukla, K. N. Ganesh, M. Sastry, Isothermal titration calorimetry on binding of DNA bases and PNA-base monomers to gold nanoparticles, J. Am. Chem. Soc. 2004, 126, 13186-13187.