Prof. LS Shashidhara



L S Shashidhara
Professor and Coordinator, Biology
E-mail: ls.shashidhara@iiserpune.ac.in
Website: http://www.ccmb.res.in/staff/shashi/droso.html

 
OFFICE :
              SAI TRINITY BUILDING
              3rd Floor,  Room no: 305
              SUTARWADI, PASHAN
              PUNE - 411021. (MAHARASHTRA)
              INDIA

L S Shashidhara

Education and previous work experience

1981-87 B.Sc. and M.Sc., University of Agricultural Sciences, Dharwad, India
1987-88 Teaching Associate, University of Agricultural Sciences, Dharwad, India
1988-91 Ph.D., Cambridge, UK
1991-93 PDF, Cambridge, UK
1993-95 Visiting Fellow, NCBS, Bangalore

1995- Scientist (Group Leader), CCMB, Hyderabad
2007- Professor (Biology), IISER, Pune



Award and Honors

CSIR Bhatnagar Award 2008 in Biological Sciences
 Fellow, Indian National Science Academy
 Fellow, Indian Academy of Sciences
 Fellow, National Academy of Sciences, India
 Honorary Faculty Member, JNCASR, Bangalore
 DAE-SRC Outstanding Research Investigator Award
 CSIR Technology award in the area of Biological Sciences

Research interests (Specialization: Genetics and Developmental Biology)

1. Evolution of appendage forms
2. Mechanism of homeotic selector (Hox) gene function

3. Functional genomics using Drosophila as a genetic system to study human genes, to develop fly models of human diseases and the application of       the same in drug discovery.

 

Recent Publications (for full list visit PubMed)

  1. Usha, N. and Shashidhara, L.S. Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. Developmental Biology (in press). (2010).
  2. Gurudatta, B.V., Shashidhara, L.S. and Parnaik., V.K. Lamin C and chromatin organization in Drosophila. J Genetics (in press). (2010).
  3. Berger, C., Ramakrishnan, K., Myneni, S., Renner, S., Shashidhara, L.S. and Technau, G.M. Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Developmental Biology 337, 415–424. (2010).
  4. Ramakrishnan, K., Berger, C., Myneni, S., Shashidhara, L.S. and Technau, G.M. Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mechanism of Development 127, 137-145. (2010).
  5. Vyas, N., Goswami, D., Manonmani, A., Sharma, P., Ranganath, H.A., VijayRaghavan, K., Shashidhara, L.S., Sowdhamini, R. and Mayor, S. Nanoscale organization of Hh is essential for long range signaling. Cell 133, 1214-1227. (2008).
  6. Gupta, R.K., Tripathi, R., Naidu, B.J., Srinivas, U.K. and Shashidhara, L.S. Cell cycle regulation by the pro-apoptotic gene Scotin. Cell Cycle 7, 2401-2408 (2008).
  7. Ramesh Rao, P., Makhijani, K. and Shashidhara, L. S.vHuman APC sequesters b-catenin even in the absence of GSK-3b in a Drosophila model. Oncogene 27, 2488-2493. (2008).
  8. Aritakula, A., Ramaswamy, A. and Shashidhara, L.S. Actin Cytoskeleton as a Putative Target of the Neem Limonoid Azadirachtin A. Insect Biochemistry and Molecular Biology 37, 627-634. (2007).
  9. Makhijani, K., Chilukuri, K., Tamarisa, S. and Shashidhara, L.S. Modulation of Decapentaplegic gradient during haltere specification in Drosophila. Developmental Biology 302, 243-255. (2007).
  10. Pallavi, S.K., Kannan, R. and Shashidhara, L.S. Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Developmental Biology 296, 340-352. (2006).
  11. Mohit, P., Makhijani, K., Madhavi, M.B., Bharathi, V., Lal, A., Sirdesai, G., Reddy, V.R., Ramesh, P., Kannan, R., Dhawan, J. and Shashidhara, L.S. Modulation of AP and DV signalling pathways by the Homeotic gene Ultrabithorax during haltere development in Drosophila. Developmental Biology 291, 356-367. (2006).
  12. Pallavi, S.K. and Shashidhara, L.S. Signaling interactions between squamous and columnar epithelia of Drosophila wing disc. J Cell Science 118, 3363-3370. (2005).
  13. Ayyub, C., Sen, A., Gonsalves, F., Kishan, B., Bhandari, P., Shashidhara L.S., Krishna, S. and Rodrigues, V. Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Developmental Dynamics 232, 865-75 (2005).
  14. Berger, C., Pallavi, S.K., Mohit, P., Shashidhara L.S. and G. M. Technau. (2005). CyclinE acts under the control of Hox-genes as a cell-fate determinant in the developing central nervous system. Cell Cycle. 4, 422-5.
  15. Berger, C., Pallavi, S.K., Mohit, P., Shashidhara L.S. and Technau, G.M. A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila. Nature Cell Biology 7, 56-62. (2005).