Prof. LS Shashidhara

L S Shashidhara
Professor and Coordinator, Biology

              Indian Institute of Science Education and Research
              Dr. Homi Bhabha Road
              Pune - 411008. (Maharashtra)

Description: Description: L S Shashidhara

Education and previous work experience

1981-87 B.Sc. and M.Sc., University of Agricultural Sciences, Dharwad, India
1987-88 Teaching Associate, University of Agricultural Sciences, Dharwad, India
1988-91 Ph.D., Cambridge, UK
1991-93 PDF, Cambridge, UK
1993-95 Visiting Fellow, NCBS, Bangalore

1995- Scientist (Group Leader), CCMB, Hyderabad
2007- Professor (Biology), IISER, Pune


Award and Honors


1.      JC Bose National Fellowship

2.      SS Bhatnagar Prize (Biological Sciences)

3.      Fellow, Indian National Science Academy

4.      Fellow, Indian Academy of Sciences

5.      Fellow, National Academy of Sciences, India

6.      Honorary Faculty Member, JNCASR, Bangalore

7.      DAE-SRC Outstanding Research Investigator Award

8.      CSIR Technology award in the area of Biological Sciences

Research interests (specialization: Genetics and Developmental Biology)

1.      Evolution of appendage forms

2.      Mechanism of homeotic selector (Hox) gene function

Recent Publications(for full list visit PubMed)  

1.      Prasad, N. and Shashidhara, LS. (2015). Gliolectin positively regulates Notch signalling during wing-vein specification in Drosophila. International Journal of Developmental Biology (in press).


2.      Agrawal, P., and Shashidhara, L.S. (2014). ChIP for Hox proteins from Drosophila imaginal discs. In Methods in Enzymology, Humana Press, Springer Publications.


3.      Subramaniam S, Sreenivas P, Cheedipudi S, Reddy VR, Shashidhara LS, Chilukoti RK, Mylavarapu M, Dhawan J. (2013). Distinct Transcriptional Networks in Quiescent Myoblasts: A Role for Wnt Signaling in Reversible vs. Irreversible Arrest. PLoS One 8, e65097.


4.      De Graeve,, F. M., Van de Bor, V., Ghiglione, C., Cerezo, D., Jouandin, P., Ueda, R., Shashidhara, L. S. and Noselli, S. (2012). Drosophila apc regulates delamination of invasive epithelial clusters. Developmental Biology 368, 7685.


5.      Agrawal, P., Habib, F., Yelagandula, R. and Shashidhara, L.S. (2011). Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection. Scientific Reports 1, DOI: 10.1038/srep00205.


6.      Ghose, A. and Shashidhara, L.S. (2011). Cyclin beyond the cell cycle: new partners at the synapse. Developmental Cell. 21, 601-12.


7.      Tripura, CB, Prafulla Chandrika, NN, Susmita, VNL, Noselli, S. and Shashidhara, LS (2011). A role for Odd-skipped in regulating JNK activity in the wing disc peripodial membrane during adult morphogenesis in Drosophila. International Journal of Developmental Biology 55, 583-90.


8.      Usha, N. and Shashidhara, L.S. (2010). Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila. Developmental Biology 341, 389399.


9.      Gurudatta, B.V., Shashidhara, L.S. and Parnaik., V.K. (2010). Lamin C and chromatin organization in Drosophila. J Genetics 89, 37-49.


10.  Berger, C., Ramakrishnan, K., Myneni, S., Renner, S., Shashidhara, L.S. and Technau, G.M. (2010). Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function. Developmental Biology 337, 415424. 


11.  Ramakrishnan, K., Berger, C., Myneni, S., Technau, G.M. and Shashidhara, L.S. (2010). Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mechanisms of Development 127, 137-145.


12.  Vyas, N., Goswami, D., Manonmani, A., Sharma, P., Ranganath, H.A., VijayRaghavan, K., Shashidhara, L.S., Sowdhamini, R. and Mayor, S. Nanoscale organization of Hh is essential for long range signaling. Cell 133, 1214-1227. (2008).


13.  Gupta, R.K., Tripathi, R., Naidu, B.J., Srinivas, U.K. and Shashidhara, L.S. Cell cycle regulation by the pro-apoptotic gene Scotin. Cell Cycle 7, 2401-2408 (2008).


14.  Ramesh Rao, P., Makhijani, K. and Shashidhara, L. S.Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model. Oncogene 27, 2488-2493. (2008).


15.  Aritakula, A., Ramaswamy, A. and Shashidhara, L.S.Actin Cytoskeleton as a Putative Target of the Neem Limonoid Azadirachtin A. Insect Biochemistry and Molecular Biology 37, 627-634. (2007).


16.  Makhijani, K., Chilukuri, K., Tamarisa, S. and Shashidhara, L.S.Modulation of Decapentaplegic gradient during haltere specification in Drosophila. Developmental Biology 302, 243-255. (2007).