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Welcome to Dr. Partha Hazra Group

Dr. Partha Hazra

Professor

Indian Institute of Science Education & Research, Pune Department of Chemistry,

Dr. Homi Bhabha Road,

Pashan, Pune, Maharashtra 411008, India

Phone: 020-2590 8077, Fax: 020-2590 8186

E-mail: p.hazra@iiserpune.ac.in

 

Present Research Interests: Spectroscopy of Materials, Photophysics and Biophysics

 

Exploring lyotropic liquid crystalline materials using fluorescence spectroscopic techniques.

 

Self-assembly Driven Tuneable Copper Nano-cluster formation and its Application towards Catalytic Activity.

 

Design, Synthesis and Photophysics of novel Thermally Activated Delayed Fluorescent (TADF) and Solid State Multi-stimuli Responsive Organic Luminogens.

 

Probing ultrafast fluorescence dynamics of metal nano-clusters.

 

Design and Synthesis of novel fluorophore for probing amyloid fibril.

 

Stabilization and Sensing of non-canonical forms of DNA, i.e., G-quadruplex, i-motif.

Glimpses of Published Works

The present study shows that a special class of ionic liquid (Gua-IL) can act as a stabilizer of telomeric GQ-DNA exerting minimal effect towards the duplex structure and thereby can be considered as a potential telomerase inhibitor. Phys. Chem. Chem. Phys., 2016, 18, 29740-29746.

Dual fluorescence property of an eminentt anticancer drug, ellipticine, has been explored to directly monitor its efficient loading into MCM-41 and subsequent release to DNA. Nanoscale, 2016, 8, 18436-18445.

Investigation of Photopyrolytic Processes of an Anticancer Drug Topotecan inside Biocompatible Lyotropic Liquid Crystalline Systems. Langmuir, 2016, 32, 3057-3065.

An antimalerial/anticancer drug, Cryptolepine is encapsulated inside the nano-cavity of cucurbit[7]uril, and its subsequent release to DNA is monitored using an external stimulus, acetylcholine chloride. ChemPhysChem, 2016, 17, 506-515.

Solvation dynamics has been investigated in different Phases of lyotropic liquid crystalline systems. J. Phys. Chem. B, 2015, 119, 11721-11731.

Femtosecond Up-conversion Studies of [2,2-Bipyridyl]-3,3-diol in Octyl-β-D-glucoside and Other Micellar Aggregates. J. Phys. Chem. A, 2015, 119, 12715-12721.

Fluorescence Switching of Sanguinarine in Micellar Environments. Phys. Chem. Chem. Phys. 2015, 17, 20725-20732.

An ionic liquid induced Green Solvent Induced DNA Package. Scientific Reports, 2015, 5, Article number: 9137.

Biophysical aspects of binding interactions between anticancer drug, Proflavine and human telomeric DNA have been monitored with different spectroscopic techniques. We have observed that Proflavine instigates and stabilizes the G-quadruplex DNA.J. Phys. Chem. B, 2014, 118, 11090-11099

Prototropical and photophysical properties of an anti-cancer drug, EPT are explored inside the inclusion complexes formed by cyclodextrins and cucurbit[n]urils using spectroscopic and computational studies.

J. Phys. Chem. B, 2013, 117, 14099-14107.

The effect of physical nanocavity on double proton transfer dynamics of BP(OH)2 is studied from femtosecond to nanosecond regime using TCSPC and fluorescence upconversion techniques. Phys. Chem. Chem. Phys. 2014, 16 (3), 933 - 939.

Prototropical and photophysical properties of an anticancer drug, ellipticine are explored inside the octyl-b-D-glucoside micelles using steady state and time resolved spectroscopic techniques. Phys. Chem. Chem. Phys. 2014, 16, 14953-14960.

Urea Induced Unfolding dynamics of Flavin Adenine Dinucleotide (FAD): Spectroscopic And Molecular Dynamics Simulation Studies from Femto-second to Nano-second regime.

J. Phys. Chem. B, 2014, 118, 1881-1890.

A clearly visible emission color switching of an anti-cancer drug, ellipticine in presence of protein (blue),

DNA (green) and protein-DNA system (sea green) promotes a novel technique to probe protein-DNA interaction. Phys. Chem. Chem. Phys. 2014, 16, 3914-3917.

TTOOCC.TIF

Sensing of Bio-molecules Using Fluorescence-Switch: Dual fluorescence property of an eminent anticancer drug, ellipticine, has been explored to directly monitor its efficient loading onto graphene oxide and subsequent release to biomolecules like DNA/RNA. Nanoscale, 2014, 6, 2937-2944.

A fluorescence switch from ultraviolet (UV) to visible (cyan) is observed as a consequence of upward pKa shift of milrinone inside the CB7 nano-cavity. Phys. Chem. Chem. Phys. 2014, 16(7), 2823-2826.

Inside the nano-cavity of CB7, ESPT of TPT is inhibited and fluorescence switches from green to blue (see picture). When NaCl is introduced into the TPT-CB7 solution, the blue colour switches back to green. ChemPhysChem, 2013, 14 3375-3383.

ESPT dynamics of a potential anti-cancer drug, Topotecan has been explored in aqueous reverse micelle using steady-state and time-resolved fluorescence measurements. J. Phys. Chem. B, 2015, 119, 2363-2371.

Cucurbit[7]uril (C7U) assists the pKa shift of an anticancer drug, 20(S)-camptothecin (CPT) by forming 2:1 (C7U:CPT) inclusion complex. However, the protonation does not take place when it is encased by β-cyclodextrin cavity. ChemPhysChem 2013, 14, 532.

The modulation over excimer formation drift of a molecular motor, called DCVJ, have been probed inside various cavity sizes of cyclodextrins host. Phys. Chem. Chem. Phys. 2013, 15, 330

The binding interactions of flavins (riboflavin (RF), flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)) with HSA have been monitored with the help of steady state and time-resolved fluorescence spectroscopy, isothermal titration calorimetry, circular dichroism studies, and supported by docking and molecular dynamics (MD) simulations studies. ChemPhysChem. 2012, 13, 2142-2153.

In this work the urea dynamics inside AOT reverse micelle has been monitored without intervention of water using time resolved fluorescence techniques from picosecond to nanosecond time regime. Urea dynamics inside the reverse micelle is severely hindered compared to dry as well as water RM due to the formation of highly networked molecular cluster of urea. J. Phys. Chem. A, 2011, 115, 10398-10407.

We have studied the solvation dynamics and rotational relaxation of Coumarin 153 (C-153) in SDS dispersed two different types of single walled carbon nanotubes (SWNTs), namely metallic and semiconducting, using picosecond fluorescence spectroscopy.

Chem. Phys. Lett., 2010, 501, 33-38.

Teaching, Research Experience & Education:

 

Professor in IISER, Pune from May, 2021 onward.

 

Associate Professor in IISER, Pune from August, 2014-April, 2021.

 

Assistant Professor in IISER, Pune from February, 2009-July, 2014.

 

Post-doctoral fellow (availed JSPS fellowship) in Kyoto University, Japan from 2004-2007 in Prof. Masahide Terazima Group.

 

2005, Ph. D. in Chemistry, Indian Institute of Technology (IIT), Kharagpur (Advisor: Prof. Nilmoni Sarkar)

 

1998, M. Sc. in Physical Chemistry, Burdwan University, India

Hydrogen Bonding Abilities of LLC Water Molecules and their Effects on Intramolecular Hydrogen Bonds of Target Probe Molecules. PCCP, 2020, Accepted.

Impact of Topology on the Characteristics of Water inside Cubic Lyotropic Liquid Crystalline Systems. J. Phys. Chem. B, 2019, 123, 18, 4118-4128.

A new approach has been explored to detect i-motif DNA structures based on the hemi-protonated cytosine-cytosine (C+-C) base pairing recognition instead of conventional loop detection of i-motif DNA. Along with its selectivity towards i-motif DNA over its complimentary GQ DNA, this approach shows its versatility by detecting different kind of i-motif structures with different chain lengths, molecularity and sizes etc. Organic & Biomolecular Chemistry (OBC) 2019, 17, 5392-5399.

Strategy to Mechanical Activation of Centro-Symmetrically Packed Organic Luminogens.

J. Phys. Chem. C, 2019, 123, 3848-3854.

Ultrafast Fluorescence Dynamics of Highly Stable Copper Nanoclusters Synthesized inside the Aqueous Nano-pool of Reverse Micelles.

J. Phys. Chem. C2018, 122, 5742-5752 .

Developing Structure-Property Relationship to Design Solid State Multi-stimuli Responsive Materials and Their Potential Applications in Different Fields. Chemical Science2018, 9, 3592-3606.