Indian Institute of Science Education and Research
Chemical Biology: Nucleic Acid Chemistry and Biophysics
Our group is interested in developing tools to assess biological events by utilizing contemporary nucleic acid functions and chemical biology. In particular, we are interested in developing biophysical tools that would enable the study of nucleic acid structure, dynamics and function in vitro and in cells. We are also interested in developing multifunctional nucleolipid conjugates that could self-assemble into nanofibres, nanotubes and gels. We expect that these self-assemblies would provide platforms for designing biosensors, biomaterials and scaffolds for nontemplate oligomerization of nucleic acids.
Dr. S. G. Srivatsan
Wellcome Trust/DBT India Senior Fellow
Dr. Homi Bhabha Road, Pashan
Congratulations to the entire group and alumni for the
Wellcome Trust/DBT India Alliance Grant
See our latest articles
1. Structure of the ribosomal decoding site RNA containing a Se-modified responsive fluorescent ribonucleoside probe.
Congratulations to Ashok and Mark
Angew. Chem. Int. Ed. 2017, 56, 2640-2644 .
2. Posttranscriptional chemical labeling of RNA by using bioorthogonal chemistry.
Congratulations to Jerrin
Methods 2017, DOI: 10.1016/j.ymeth.2017.02.004.
3. Responsive fluorescent PNA analog as a tool for detecting G-quadruplex motifs of oncogenes
Congratulations to Pramod
ChemBioChem 2016, 17, 1665-1673.
4. Clickable UTP analog for the posttranscriptional chemical labeling and imaging of RNA.
Congratulations to Anupam
Org. Biomol. Chem., 2016, 14, 5832-5842.
5. Hierarchical self-assembly of switchable nucleolipid supramolecular gels based on environment-sensitive fluorescent nucleoside analogs.
Congratulations to Ashok
Nanoscale 2016, 8, 3607-3619.
6. A versatile toolbox for posttranscriptional chemical labeling and imaging of RNA.
Congratulations to Anupam and Arun
Nucl. Acid. Res. 2016, 44, e16.