Indian Institute of Science Education and Research


Srivatsan Group


Chemical Biology: Nucleic Acid Chemistry and Biophysics

Our group is interested in developing tools to assess biological events by utilizing contemporary nucleic acid functions and chemical biology. In particular, we are interested in developing biophysical tools that would enable the study of nucleic acid structure, dynamics and function in vitro and in cells. We are also interested in developing multifunctional nucleolipid conjugates that could self-assemble into nanofibres, nanotubes and gels. We expect that these self-assemblies would provide platforms for designing biosensors, biomaterials and scaffolds for nontemplate oligomerization of nucleic acids.

Contact address

Dr. S. G. Srivatsan

Associate Professor

Wellcome Trust/DBT India Senior Fellow

Chemistry Division


Dr. Homi Bhabha Road, Pashan
Pune 411008, India

Tel.: +91-20-25908086

Fax: +91-20-25908186


Lab News


Congratulations to the entire group and alumni for the

Wellcome Trust/DBT India Alliance Grant

See our latest articles

1.  Structure of the ribosomal decoding site RNA containing a Se-modified responsive fluorescent ribonucleoside probe.

Congratulations to Ashok and Mark

Angew. Chem. Int. Ed. 2017, 56, 2640-2644 .

2. Posttranscriptional chemical labeling of RNA by using bioorthogonal chemistry.

Congratulations to Jerrin

Methods 2017, DOI: 10.1016/j.ymeth.2017.02.004.

3. Responsive fluorescent PNA analog as a tool for detecting G-quadruplex motifs of oncogenes

Congratulations to Pramod

ChemBioChem 2016, 17, 1665-1673.

4. Clickable UTP analog for the posttranscriptional chemical labeling and imaging of RNA.

Congratulations to Anupam

Org. Biomol. Chem., 2016, 14, 5832-5842.

5. Hierarchical self-assembly of switchable nucleolipid supramolecular gels based on environment-sensitive fluorescent nucleoside analogs.

Congratulations to Ashok

Nanoscale 2016, 8, 3607-3619.

6. A versatile toolbox for posttranscriptional chemical labeling and imaging of RNA.

Congratulations to Anupam and Arun

Nucl. Acid. Res. 2016, 44, e16.