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Srivatsan Group

 

Chemical Biology: Nucleic Acid Chemistry, Biophysics, Self-assemblies

We use simple physical organic concepts to develop tools to assess structure, dynamics and function of nucleic acids in cell-free and complex cellular environments. In this direction, we have initiated two research programs. One involves the development of minimally perturbing and conformation-sensitive multi-app nucleoside probes for studying nucleic acids in real time by fluorescence, in 3D by X-ray crystallography and in cells by NMR. In the second program, we establish methods to label nucleic acids with variety of functionalities by using bioorthogonal chemistry like click and metal-catalyzed reactions. In parallel, we are also interested in developing multifunctional nucleolipid conjugates that self-assemble into nanofibres, nanotubes and gels. These assemblies show aggregation-induced fluorescence, self-sorting behavior and surface-switchable properties. Our research is multidisciplinary in nature involving synthetic organic chemistry, biophysics, molecular, cell and structural biology.

Our research in youtube: https://www.youtube.com/watch?v=7CFzZjauYl8

Srivatsan interview: https://www.youtube.com/watch?v=DLV32SCIuuo

Our efforts in COVID research: https://www.youtube.com/watch?v=KarLWR3CvzQ

 

Contact address

Professor S. G. Srivatsan

Department of Chemistry

Associate Dean R&D

Wellcome Trust/DBT India Senior Fellow

Chemistry Division

IISER, Pune

Dr. Homi Bhabha Road, Pashan
Pune 411008, India

Tel.: +91-20-25908086

E-mail: srivatsan@iiserpune.ac.in

Lab News

 

Srivatsan extends his sincere thanks to all the former and present members of his laboratory for their immense contribution, which has lead to national and international recognition:

1. National Prize for Research on Chemistry of Peptides and Nucleic Acids 2020 (Sponsored by CNR Rao Education Foundation)

2. Chemical Research Society of India (CRSI) Bronze medal for 2020

3. CDRI awards 2019 for Excellence in Drug Research

4. Editorial Advisory Board member of ACS Bioconjugate Chemistry

 

Recent articles

Congratulations to Jerrin T. George for his recent publications in JACS and ChemComm

1. George, J. T.; Srivatsan, S. G.* Responsive fluorescent nucleotides serve as efficient substrates to probe terminal uridylyl transferase. Chem. Commun. 2020, doi.org/10.1039/D0CC05092J.

2. George, J. T.; Mohd. Azhar; Aich, M.; Sinha, D.; Ambi, U. B.; Maiti, S.;* Chakraborty, D.;* Srivatsan, S. G.* Terminal uridylyl transferase mediated site-directed access to clickable chromatin employing CRISPR-dCas9. J. Am. Chem. Soc. 2020, doi.org/10.1021/jacs.0c06541.

3. Sontakke, V. A.; Srivatsan, S. G.* Bioorganic & Medicinal Chemistry Letters 2020, 30, 127345.

4. Nuthanakanti, A.; Srivatsan, S. G.* Multi-stimuli responsive heterotypic hydrogels based on nucleolipids show selective dye adsorption. Nanoscale Adv. 2020, DOI: 10.1039/D0NA00509F.

5. Manna, S.; Srivatsan, S. G.* Synthesis and enzymatic incorporation of a responsive ribonucleoside probe that enables quantitative detection of metallo-base pairs. Org. Lett. 2019, 21, 4646-4650.

6. Ashok, N.; Ishtiyaq, A.; Saddam, Y. K.; Kayarat, S.;* Srivatsan, S. G.* Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe. Nucl. Acid. Res. 2019, 47, 6059-6072.

7. Manna, S.; Sarkar, D.; Srivatsan, S. G.* A Dual-app nucleoside probe provides structural insights into the human telomeric overhang in live cells. J. Am. Chem. Soc. 2018, 140, 12622-12633.

8. Walunj, M. B.; Tanpure, A. A.; Srivatsan, S. G.* Posttranscriptional labeling by using Suzuki-Miyaura cross-coupling generates functional RNA probes. Nucl. Acid. Res. 2018, 46, e65.