Department of
Chemistry

Buddhadeb Chattopadhyay obtained his PhD (Supervisor: Professor K. C. Majumdar) from the University of Kalyani in 2009. He then spent around six years in the USA (University of Chicago at Illinois at Chicago and Michigan State University) for his postdoctoral research. Before joining IISER Pune, Buddhadeb served more than ten years at the Centre of Biomedical Research (CBMR), Lucknow in the positions of Assistant Professor, Associate Professor, and Additional Professor.

Research

Catalyst engineering for C–H bond borylation, Metalloradical catalysis

Dr. Buddhadeb Chattopadhyay's research interest includes the catalyst/ligand engineering for the C–H bond activation/functionalization, especially C–H bond borylations of organic molecules and metal-nitrene/carbene chemistry. The group employs metalloradical catalysis by means of denitrogenative transformations to make high-valued nitrogen heterocycles.

Selected Publications

1. Formal Ir-Catalyzed Ligand-Enabled Ortho- and Meta-Borylation of Aromatic Aldehydes via in Situ Generated  Imines. Bisht, R.; Chattopadhyay, B. J. Am. Chem. Soc. 2016, 138, 84-87.
2. Noncovalent Interactions in Ir-Catalyzed C–H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters. Hoque, E.; Bisht, R.; Haldar, C.; Chattopadhyay, B. J. Am. Chem. Soc. 2017, 139, 7745-7748.
3. Ir-Catalyzed Intramolecular Transannulation/C(sp2)–H Amination of 1,2,3,4-Tetrazoles by Electrocyclization. Das, S. K.; Roy, S.; Khatua, H.; Chattopadhyay, B. J. Am. Chem. Soc. 2018, 140, 8429-8433.
4. Iron-Catalyzed Amination of Strong Aliphatic C(sp3)–H Bonds.  Sandip  Kumar Das,   Satyajit Roy,   Hillol Khatua,  Chattopadhyay, B. J. Am. Chem. Soc. 2020, 142, 16211-16217.
5. Remarkably Efficient Iridium Catalysts for Directed C(sp2)−H and C(sp3)−H Borylation of Diverse Classes of Substrates. Hoque, E.; Hassan, M. M. M.; Chattopadhyay, B. J. Am. Chem. Soc. 2021, 143, 5022–5037.
6. Meta Selective C–H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction. Chaturvedi, J.; Haldar, C.; Bisht, R.; Pandey, G.; Chattopadhyay, B. J. Am. Chem. Soc. 2021, 143, 7604-7611.
7. Iron-Catalyzed Intermolecular Amination of Benzylic C(sp3)–H Bonds. Khatua, H.; Das, S.; Patra, S.; Das, S. K.; Roy, S.; Chattopadhyay, B. J. Am. Chem. Soc. 2022, 144, 21858–21866.
8. Iron-Catalyzed Intermolecular C–N Cross-Coupling Reactions via Radical Activation Mechanism. Das, S.; Ehlers, A. W.; Patra, S.; de Bruin, B.; Chattopadhyay, B. J. Am. Chem. Soc. 2023, 145, 14599–14607.
9. A tautomerized ligand enabled meta selective C–H borylation of phenol. Guria, S.; Hassan, M. M. M.; Ma, J.; Dey, S.; Liang, Y.; Chattopadhyay, B. Nature Commun. 2023, 14, 6906.
10. Sterically Controlled Lewis Acid–Base Interaction Toward para-Selective Borylation of Aromatic Aldimines and Benzylamines. Guria, S.; Hassan, M. M. M.; Dey, S.; Singh, K. N.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2024, 63, e202409010.