Department of
Chemistry

Manickam Jayakannan (JK) has obtained his PhD degree from Indian institute of science, Bangalore, India (2000) and undertook his post-doctoral studies at Eindhoven University of Technology, The Netherlands (2000-2001). He worked as a polymer scientist at JFWTC General Electric R&D (2002), Bangalore and as a scientist at CSIR-NIIST (2003-2007) Trivandrum, prior to joining IISERPune in 2007 as Assistant Professor to embark the journey of building the new academic institute. He is currently continuing as a Professor in the chemistry department.

Research

Synthetic polymers and biomaterials

Synthetic polymer chemistry knowledge is applied to address problems at chemistry-biology interface and efforts are taken to teach and train undergraduate and research students to handle next generation global issues relevant to healthcare. Research programmes are emphasized in designing macromolecular architectures to generate new knowledge and technology in the area of biomaterial science. Students and post docs having excellent academic records are most welcome to join the research group to embark on the journey of “Pursuit of Science in Finding the Truth.”

Selected Publications

Deshpande, Nilesh Umakant; Virmani, Mishika; Jayakannan, Manickam (2021). AIE-driven fluorescent polysaccharide polymersome as enzyme-responsive FRET nanoprobe to study the real-time delivery aspects in live-cells. Polymer Chemistry, 12(10), 1549-1561. DOI:10.1039/d0py01085e

Ghosh, Ruma; Malhotra, Mehak; Madhuri Sathe, Rupali Ravindra; Jayakannan, Manickam (2020). Biodegradable polymer theranostic fluorescent nanoprobe for direct visualization and quantitative determination of antimicrobial activity. Biomacromolecules, 21(7), 2896-2912. DOI:10.1021/acs.biomac.0c00653

Saxena, Sonashree; Jayakannan, Manickam (2020). Development of L-Amino-Acid-Based Hydroxyl Functionalized biodegradable amphiphilic polyesters and their drug delivery capabilities to cancer cells. Biomacromolecules, 21(1), 171-187. DOI:10.1021/acs.biomac.9b01124

Kulkarni, Bhagyashree; Malhotra, Mehak; Jayakannan, Manickam (2019). Perylene-tagged polycaprolactone block copolymers and their enzyme-biodegradable fluorescent nanoassemblies for intracellular bio-imaging in cancer cells. ACS Applied Polymer Materials, 1(12), 3375-3388. DOI:10.1021/acsapm.9b00800

Saxena, Sonashree; Pradeep, Anu; Jayakannan, Manickam (2019). Enzyme-responsive theranostic FRET probe based on L-Aspartic amphiphilic polyester nanoassemblies for intracellular bioimaging in cancer cells. ACS Applied Bio Materials, 2(12), 5245-5262. DOI:10.1021/acsabm.9b00450

Joshi, Dheeraj Chandra; Saxena, Sonashree; Jayakannan, Manickam (2019). Development of L-Lysine based biodegradable polyurethanes and their dual-responsive amphiphilic nanocarriers for drug delivery to cancer cells. ACS Applied Polymer Materials, 1(7), 1866-1880. DOI:10.1021/acsapm.9b00413

Deshpande, Nilesh Umakant; Jayakannan, Manickam (2018). Biotin-tagged polysaccharide vesicular nanocarriers for receptor-mediated anticancer drug delivery in cancer cells. Biomacromolecules, 19(8), 3572-3585. DOI:10.1021/acs.biomac.8b00833

Inchanalkar, Siddhi; Deshpande, Nilesh Umakant; Kasherwal, Vishakha; Jayakannan, Manickam; Balasubramanian, Nagaraj (2018). Polymer nanovesicle-mediated delivery of MLN8237 preferentially inhibits Aurora Kinase A to target RalA and anchorage-independent growth in breast cancer cells. Molecular Pharmaceutics, 15(8), 3046-3059. DOI:10.1021/acs.molpharmaceut.8b00163

Aluri, Rajendra; Saxena, Sonashree; Joshi, Dheeraj Chandra; Jayakannan, Manickam (2018). Multistimuli-responsive amphiphilic poly(ester-urethane) nanoassemblies based on L-Tyrosine for intracellular drug delivery to cancer cells. Biomacromolecules, 19(6), 2166-2181. DOI:10.1021/acs.biomac.8b00334