Photophysics and biophysics
Photophysics and biophysics
Partha Hazra obtained his PhD from IIT Kharagpur in 2005. After that I moved to Kyoto University, Japan for a post-doctoral fellowship, and there I availed JSPS fellowship from 2005 to 2007. I joined in the Department of Chemistry, IISER Pune as an Assistant Professor in the year 2008. Presently, I am a full Professor in the Department of Chemistry, IISER Pune.
(a) Design, Synthesis and Photophyiscs of Novel Thermally Activated Delayed Fluorescence (TADF), Room Temperature Phosphorescent and Mechanochromic Fluorescent Luminogens:
One of the most capable accelerators for the development of “all in one” type future generation luminogens is the triplet state engineering, which involves phenomena, like thermally activated delayed fluorescence (TADF) and room temperature phosphorescence (RTP). In particular, RTP has drawn considerable attention owing to its potential application for optoelectronic devices as well as for biological applications. Thus, we are trying to design novel organic luminogens which can exhibit TADF and RTP properties along with mechanochromic properties, and thereby they can be used in the design of optoelectronic devices and in biological applications.
(b) Self-assembly Mediated Broadband Emission Tunability of Luminescent Metal Nano-clusters:
Ultra-small size, greater photo-stability, and tunable fluorescence make these metal nanocluster excellent alternatives to quantum dots and organic dyes for various applications. Self-assembled metal nanoclusters have numerous applications in different fields such as, biomedicine, drug delivery, bio-imaging, optoelectronic utilizations and catalytic applications. Our primary motive is to synthesize the single metal nanoclusters at first and after that we use those single cluster particles as a building block to form nanocluster superstructures with additional properties and enhanced functionalities for further catalytic applications.
(c) Designing of Novel Fluorophores for Probing Amyloid Fibril:
Several small organic molecules have been designed for the optical imaging of amyloid fibrils. Most of the cases the detection is based on the enhancement of fluorescence intensity of the probes, which are always susceptible to self-quenching at higher concentrations. In continuation of this effort, here we are going to introduce a series of donor acceptor-based charge transfer probe molecules, which forms AIE dots in buffer, and able to sense insulin amyloid fibrils in terms of disaggregation induced fluorescence switching and fluorescence enhancement.
Das, K. Sappati, S. Bisht, G. S. and Hazra, P*. Proton-Coupled Electron Transfer in the Aqueous Nanochannels of Lyotropic Liquid Crystals: Interplay of H-Bonding and Polarity Effects. J. Phys. Chem. Lett. 2021, 12, 2651-2659.
Roy, B. Reddy, M. C. Jose, G.P. Niemeyer, F. C. Voskuhl, J. Hazra, P*. All in One: Stimuli-Responsive, Efficient Mitotracking, and Single Source White Light Emission. J. Phys. Chem. Lett. 2021, 12, 1162-1168.
Uddin, A. Roy, B. Jose, G. P. Hossain Sk. S. and Hazra, P*. Sensing and Modulation of Amyloid Fibrils by Photo-switchable Organic Nano-dots. Nanoscale, 2020, 12, 16805-16818.
Das, K. Sappati, S. and Hazra, P*. Peculiar Hydrogen Bonding Behaviour of Water Molecules inside the Aqueous Nanochannels of Lyotropic Liquid Crystals. Phys. Chem. Chem. Phys., 2020, 22, 6210-6221.
Das, K. Roy, B. Satpathi, S. and Hazra, P*. Impact of Topology on the Characteristics of Water Inside Cubic Lyotropic Liquid Crystalline Systems. J. Phys. Chem. B, 2019, 123, 4118-4128.
Satpathi, S. Das, K. and Hazra, P*. Silica nano-channel induced i-motif formation and stabilization at neutral and alkaline pH. Chemical Communications, 2018, 54, 7054-7057.
Roy, B. Reddy, M. C. Hazra, P*. Developing Structure-Property Relationship to Design Solid State Multi-Stimuli Responsive Materials and Their Potential Applications in Different Fields. Chemical Science, 2018, 9, 3592-3606.
Koninti, R. Satpathi, S. and Hazra, P* Ultrafast Fluorescence Dynamics of Highly Stable Copper Nanoclusters Synthesized Inside the Aqueous Nano-Pool of Reverse Micelles. J. Phys. Chem. C, 2018, 122, 5742-5752.