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Department of

Photo of S. Sandanaraj Britto

S. Sandanaraj Britto

Assistant Professor


Chemical biology/physiology, Optical molecular imaging of whole organisms


Sandanaraj Britto obtained PhD at the University of Massachusetts-Amherst (2002-2007). He was a Presidential Postdoctoral Fellow until 2010 at the Global Imaging Group of Novartis Institutes for BioMedical Research, Inc at Cambridge, Massachusetts, USA. He worked as Senior Scientist in RNAi Therapeutics at Novartis until 2014 before joining IISER Pune.


Development of enabling chemical biology technologies

The second half of 20th century has witnessed the prowess of chemist's to design and engineer elegant complex molecules. However, there was a shift in the paradigm towards syntheses of molecules with defined function rather than defined structure. As the focus of chemistry changes from structure to function, the present challenge of chemical community is "Synthesis of New Function through engineering of small molecule and biomacromolecules". Towards that goal, Dr. Britto's group interest is in designing new (macro) molecules for applications in the area of Chemical Biology/Physiology and Molecular Imaging.

Selected Publications

Reddy, M.M., Bathla, P., Sandanaraj, B.S. A universal chemical method for rational design of protein-based nanoreactors. ChemBioChem, 2021  Link

Bhandari, P. B., Sandanaraj, B.S. Rational design of programmable monodisperse semi-synthetic protein nanomaterials containing engineered disulfide functionality. ChemBioChem, 2021 Link (Made it to top 20% and to be appear in the cover page)

Bhandari, P.B., Reddy, M.M., Jagan, K., Sandanaraj, B.S. Expedient chemical synthesis of self-assembling semi-synthetic proteins. J. Org. Chem. 2021, 86, 8576-8589

Bhandari, P.B., Sandanaraj, B.S. Programmed and sequential disassembly of multi-responsive supramolecular protein nanoassemblies: A detailed mechanistic investigation. ChemBioChem 2021, 22, 876-887

Bathla. P., Sandanaraj, B.S. Development of activity-based reporter gene technology for an exquisite imaging of protease function in single live cell. ACS Chem Biol 2019, 14, 2276-2285

Sandanaraj, B.S., Bhandari, P.J., Reddy, M.M., Lohote, A.B., Sahoo, B. Design, synthesis and self-assembly studies of suite of monodisperse facially amphiphilic protein-dendron conjugates. ChemBioChem 2019, 21, 408-416

Sandanaraj, B.S., Reddy, M.M., Jagan, K., Bhandari, P.J. Rational design of semi-synthetic protein complexes with the defined oligomeric state. Chem. Select. 2019, 4, 6397-6402

Sandanaraj, B.S., Reddy, M.M., Bhandari, P., Sugam, K., Aswal, V. K. Rational design of supramolecular dynamic protein assemblies using a micelle-assisted activity-based protein labelling technology. Chem. Eur. J. 2018, 24, 16085-16096. (Chosen as a hot paper in Chemical Biology Category – Highlighted in ChemView Magazine, Pune Mirror Newspaper)