A microscopy image showing layers in different colors and a network of neurons

Department of

Photo of Aurnab  Ghose

Aurnab Ghose






Aurnab Ghose read Biology and Chemistry at Presidency College, Calcutta, India followed by a Masters from the University of Leicester, UK. His PhD research was conducted at The Beatson Institute for Cancer Research, UK. Following postdoctoral research at the Dept. of Cell Biology, Harvard Medical School, USA, he joined the faculty of IISER Pune where his group studies the development and function of neural circuits.


Development and functional plasticity of neural circuits

Prof. Aurnab Ghose's group employs quantitative cell biology, biophysical measurements, activity imaging and behavioural analysis to explore two aspects of the nervous system.

Theme 1: The ontogeny and homoeostasis of neural circuits, with emphasis on cytoskeleton remodelling and cellular biomechanics

Theme 2: Functional modulation of neural circuits by neuropeptides and integration of internal states with behavioural outputs

Selected Publications

Bodas, D.S.*, Maduskar, A.*, Kaniganti, T., Wakhloo, D., Balasubramanian, A., Subhedar, N. and Ghose, A. (2023) Convergent energy state-dependent antagonistic signalling by Cocaine- and amphetamine-regulated transcript and Neuropeptide Y modulates the plasticity of forebrain neurons to regulate feeding in zebrafish. J Neurosci, 2023, 43(7):1089-1110. doi: 10.1523/JNEUROSCI.2426-21.2022  * equal contribution

Kundu, T., Das, S.S., Sewatkar, L.K., Kumar, D.S., Nagar, D. and Ghose, A. (2022) Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching. J Neurosci, 2022, 42(39), 7355-7369. doi: 10.1523/JNEUROSCI.3107-20.2022

Nagar, D., James, T.K., Mishra, R., Guha, S. and Ghose, A. (2021) The formin Fmn2b is required for the development of an excitatory interneuron module in the zebrafish acoustic startle circuit. eNeuro, 8(4), doi: 10.1523/ENEURO.0329-20.2021 

Kundu, T.*, Dutta, P.*, Nagar, D., Maiti, S., Ghose, A. (2021) Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones. J Cell Sci, 134(13), doi: 10.1242/jcs.252916          * equal contribution

Dubey, S., Bhembre, N., Bodas, S., Veer, S., Ghose, A., Callan-Jones, A. and Pullarkat, P.A. (2020) The axonal actin-spectrin skeleton acts as a tension buffering shock absorber. eLife, 9:e51772, doi: 10.7554/eLife.51772 

Mutalik, S.P., Joseph, J., Pullarkat, P.A. and Ghose, A. (2018) Cytoskeletal mechanisms of axonal contractility. Biophys J, 115(4), 713-724. 

Rale, A., Shendye, N., Bodas, D.S., Subhedar, N. and Ghose, A. (2017) CART neuropeptide modulates the extended amygdalar CeA-vBNST circuit to gate expression of innate fear. Psychoneuroendocrinol, 85, 69-77. 

Sahasrabudhe, A., Ghate, K., Mutalik, S., Jacob, A. and Ghose, A. (2016) Formin-2 regulates stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo. Development, 143, 449-460.