A microscopy image showing layers in different colors and a network of neurons

Department of
Biology

Photo of L. S. Shashidhara

L. S. Shashidhara

Professor (currently on lien to Ashoka University)

Biology

Evolution of appendage forms, functional genomics, drug discovery

+91-20-25908059

ls.shashidhara@iiserpune.ac.in

L.S. Shashidhara specialises in Genetics, Molecular Biology and Evolutionary biology. His group has identified key mechanisms that specify organ development and regulate growth control during embryonic development. They have also expanded their study to examine the status of these evolutionarily conserved mechanisms in epithelial cancers in human.

Prof. Shashidhara did his undergraduate and post-graduate studies at the University of Agricultural Sciences, Dharwad, India and holds PhD from the University of Cambridge, UK.

Research

Organ specification, development and growth control

Using the fruitfly Drosophila melanogaster as a model system, Prof. Shahshidhara's group is addressing two fundamental questions in biology: (i) What is the mechanism by which the various cells/tissues/organs are positioned in their respective places in our body? (ii) How are shape and size of different organs determined? The group has identified key mechanisms that specify organ development and regulate growth control in Drosophila, and have also expanded their study by including human clinical samples to examine the status of these evolutionarily conserved mechanisms in various epithelial cancers.

Selected Publications

Nagarkar, S., Wasnik, R., Govada, P., Cohen, S.M. and Shashidhara, L.S. (2020). Promoter proximal pausing limits Yki-induced tumorous growth in Drosophila. Genetics. 216, 67-77. Link

De las Heras, J.M., Garcia-Cortes, C., Foronda, D., Pastor-Pareja, J.C., Shashidhara, L.S. and Sanchez-Herrero, E. (2018). The Drosophila Hox gene Ultrabithorax controls appendage shape by regulating extracellular matrix dynamics. Development 145, dev161844. Link

Shukla, J.P., Deshpande, G. and Shashidhara, L.S. (2017). Ataxin-2 binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster. Development 144, 905-915. Link

Prasad, N.*, Tarikere, S.*, Khanale, D., Habib, F. and Shashidhara, L.S. (2016). A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species. Scientific Reports 6, 27885; doi: 10.1038/srep27885. * equal contribution. Link

Singh, S., Sánchez-Herrero, E. and Shashidhara, L.S. (2015). Critical role for Fat/Hippo and IIS/Akt pathways downstream of Ultrabithorax during haltere specification in Drosophila. Mechanisms of Development 138 (Pt 2), 198-209. Link

Agrawal, P., Habib, F., Yelagandula, R. and Shashidhara, L.S. (2011). Genome-level identification of targets of Hox protein Ultrabithorax in Drosophila: novel mechanisms for target selection. Scientific Reports 1, DOI: 10.1038/srep00205 Link