Department of
Biology

Siddhesh Kamat is currently a Professor, and a Swarna Jayanti Fellow in the Department of Biology at IISER Pune. Prof. Kamat completed his B. Tech from the Institute of Chemical Technology (former UDCT) in 2007, and a PhD from the Department of Chemistry at Texas A&M University in 2012. Prof. Kamat was the 9th Irving S. Sigal Postdoctoral Fellow of the American Chemical Society at the Department of Chemical Physiology, The Scripps Research Institute. He joined IISER Pune in 2016.

Research

Chemical biology of mammalian lipid signalling pathways

Prof. Siddhesh Kamat's group is interested in studying the biological mechanisms of lipid signaling pathways in the mammalian nervous and immune system. To achieve their goals, the group integrates aspects of chemical biology, biochemistry, molecular and cell biology, immunology, animal and/or cellular models, in conjunction with advanced mass spectrometry (LC-MS) based metabolomics and proteomics techniques. The long term goal is to identify and understand as-of-yet uncharacterized lipid signaling pathways in vivo, annotate enzymes and receptors that regulate their biology and provide new insights and therapeutic paradigms for orphan and/or emerging human neurological and immunological diseases.

Selected Publications

1. Shanbhag, K., Mhetre, A., Saharan, O., Devarajan, A., Rai, A., Madhusudhan, M. S., Chakrapani, H.*, Kamat, S. S.* (2025) Chemoproteomics identifies protein ligands for monoacylglycerol lipids, Communications Chemistry 8, 197. 
2. Manna, S., Gupta, S., Bora, P., Chakraborty, A., Kumar, A. T., Kamat, S. S.*, Chakrapani, H.* (2025) Tandem biocatalysis to generate hydrogen sulphide and promote endogenous antioxidant response, Angewandte Chemie 64 (24), e202502917. 
3. Chakraborty, A., Devarajan, A., Kumar, K., Rohith, C. S., Madhusudhan, M. S., Ratnaparkhi, G. S., Kamat, S. S.* (2025) Bioinformatics analysis identifies sequence determinants of enzymatic activity for the PHARC associated lipase ABHD12, Biochemistry 64 (8), 1852-1863. 
4. Chakraborty, A., Punnamraju, P., Sajeevan, T., Kaur, A., Kolthur-Seetharam, U., Kamat, S. S.* (2025) Identification of ABHD6 as a lysophosphatidylserine lipase in the mammalian liver and kidneys, J. Biological Chemistry 301 (2), 108157, 1-13.
5. Chakraborty, A., Kamat, S. S.* (2024) Lysophosphatidylserine: a signaling lipid with implications in human diseases, Chemical Reviews 124 (9), 5470 – 5504. 
6. Chandramouli, A., Kamat, S. S.* (2024) A facile LC-MS method for profiling cholesterol and cholesteryl esters in mammalian cells and tissues, Biochemistry 63 (18), 2300-2309. 
7. Rajendran, A., Soory, A., Khandelwal, N., Ratnaparkhi, G. S., Kamat, S. S.* (2022) A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals, J. Biological Chemistry 298 (7), 102128, 1-14. 
8. Mehdiratta, K., Singh, S., Sharma, S., Bhosale, R. S., Choudhary, R., Masal, D. P., Manocha, A., Dhamale, B. D., Khan, N., Vivekanand, A., Sharma, P., Ikeh, M., Brown A. C., Parish, T., Ojha, A., Michael, J. S., Faruq, M., Medigeshi, G. R., Mohanty, D., Reddy, D. S., Natarajan, V. T., Kamat, S. S.*, Gokhale, R. S.* (2022) Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis, PNAS 119(8), e2110293119. 
9. Khandelwal, N., Shaikh, M., Mhetre, A., Singh, S., Sajeevan, T., Joshi, A., Balaji, K. N., Chakrapani, H., Kamat, S. S.* (2021) Fatty acid chain length drives lysophosphatidylserine dependent immunological outputs, Cell Chemical Biology 28, 1169-1179. 
10. Kelkar, D. S., Ravikumar, G., Mehendale, N., Singh, S., Joshi, A., Sharma, A. K., Mhetre, A., Rajendan, A., Chakrapani, H., Kamat, S. S.* (2019) A chemical genetic screen identifies ABHD12 as an oxidized phosphatidylserine lipase, Nature Chemical Biology 15, 169-178.